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name : strelka_somatic
description : Strelka2 is a fast and accurate small variant caller optimized for analysis of germline variation in small cohorts and somatic variation in tumor/normal sample pairs
keywords :
- variant calling
- germline
- wgs
- vcf
- variants
tools :
- strelka :
description : Strelka calls somatic and germline small variants from mapped sequencing reads
homepage : https://github.com/Illumina/strelka
documentation : https://github.com/Illumina/strelka/blob/v2.9.x/docs/userGuide/README.md
tool_dev_url : https://github.com/Illumina/strelka
doi : 10.1038 /s41592-018-0051-x
licence : [ 'GPL v3' ]
input :
- meta :
type : map
description : |
Groovy Map containing sample information
e.g. [ id:'test', single_end:false ]
- cram_normal :
type : file
description : BAM/CRAM/SAM file
pattern : "*.{bam,cram,sam}"
- crai_normal :
type : file
description : BAM/CRAM/SAM index file
pattern : "*.{bai,crai,sai}"
- cram_tumor :
type : file
description : BAM/CRAM/SAM file
pattern : "*.{bam,cram,sam}"
- crai_tumor :
type : file
description : BAM/CRAM/SAM index file
pattern : "*.{bai,crai,sai}"
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- manta_candidate_small_indels :
type : file
description : VCF.gz file
pattern : "*.{vcf.gz}"
- manta_candidate_small_indels_tbi :
type : file
description : VCF.gz index file
pattern : "*.tbi"
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- fasta :
type : file
description : Genome reference FASTA file
pattern : "*.{fa,fasta}"
- fai :
type : file
description : Genome reference FASTA index file
pattern : "*.{fa.fai,fasta.fai}"
- target_bed :
type : file
description : BED file containing target regions for variant calling
pattern : "*.{bed}"
- target_bed_tbi :
type : file
description : Index for BED file containing target regions for variant calling
pattern : "*.{bed.tbi}"
output :
- meta :
type : map
description : |
Groovy Map containing sample information
e.g. [ id:'test', single_end:false ]
- vcf_indels :
type : file
description : Gzipped VCF file containing variants
pattern : "*.{vcf.gz}"
- vcf_indels_tbi :
type : file
description : Index for gzipped VCF file containing variants
pattern : "*.{vcf.gz.tbi}"
- vcf_snvs :
type : file
description : Gzipped VCF file containing variants
pattern : "*.{vcf.gz}"
- vcf_snvs_tbi :
type : file
description : Index for gzipped VCF file containing variants
pattern : "*.{vcf.gz.tbi}"
- versions :
type : file
description : File containing software versions
pattern : "versions.yml"
authors :
- "@drpatelh"