diff --git a/modules/ensemblvep/Dockerfile b/modules/ensemblvep/Dockerfile
index b4a1c664..4ada7c6b 100644
--- a/modules/ensemblvep/Dockerfile
+++ b/modules/ensemblvep/Dockerfile
@@ -11,8 +11,8 @@ RUN conda env create -f /environment.yml && conda clean -a
 # Setup default ARG variables
 ARG GENOME=GRCh38
 ARG SPECIES=homo_sapiens
-ARG VEP_VERSION=104
-ARG VEP_TAG=104.3
+ARG VEP_VERSION=105
+ARG VEP_TAG=105.0
 
 # Add conda installation dir to PATH (instead of doing 'conda activate')
 ENV PATH /opt/conda/envs/nf-core-vep-${VEP_TAG}/bin:$PATH
diff --git a/modules/ensemblvep/build.sh b/modules/ensemblvep/build.sh
index 650c8704..402f2434 100755
--- a/modules/ensemblvep/build.sh
+++ b/modules/ensemblvep/build.sh
@@ -20,9 +20,9 @@ build_push() {
     docker push nfcore/vep:${VEP_TAG}.${GENOME}
 }
 
-build_push "GRCh37"    "homo_sapiens"           "104" "104.3"
-build_push "GRCh38"    "homo_sapiens"           "104" "104.3"
-build_push "GRCm38"    "mus_musculus"           "102" "104.3"
-build_push "GRCm39"    "mus_musculus"           "104" "104.3"
-build_push "CanFam3.1" "canis_lupus_familiaris" "104" "104.3"
-build_push "WBcel235"  "caenorhabditis_elegans" "104" "104.3"
+build_push "GRCh37"    "homo_sapiens"           "105" "105.0"
+build_push "GRCh38"    "homo_sapiens"           "105" "105.0"
+build_push "GRCm38"    "mus_musculus"           "102" "105.0"
+build_push "GRCm39"    "mus_musculus"           "105" "105.0"
+build_push "CanFam3.1" "canis_lupus_familiaris" "105" "105.0"
+build_push "WBcel235"  "caenorhabditis_elegans" "105" "105.0"
diff --git a/modules/ensemblvep/environment.yml b/modules/ensemblvep/environment.yml
index c0731c26..5df85b80 100644
--- a/modules/ensemblvep/environment.yml
+++ b/modules/ensemblvep/environment.yml
@@ -1,10 +1,10 @@
 # You can use this file to create a conda environment for this module:
 #   conda env create -f environment.yml
-name: nf-core-vep-104.3
+name: nf-core-vep-105.0
 channels:
   - conda-forge
   - bioconda
   - defaults
 
 dependencies:
-  - bioconda::ensembl-vep=104.3
+  - bioconda::ensembl-vep=105.0