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taxprofiler/subworkflows/local/visualization_krona.nf
2022-10-05 13:40:43 +02:00

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//
// Create Krona visualizations
//
include { MEGAN_RMA2INFO as MEGAN_RMA2INFO_KRONA } from '../../modules/nf-core/megan/rma2info/main'
include { KAIJU_KAIJU2KRONA } from '../../modules/nf-core/kaiju/kaiju2krona/main'
include { KRAKENTOOLS_KREPORT2KRONA } from '../../modules/nf-core/krakentools/kreport2krona/main'
include { KRONA_CLEANUP } from '../../modules/local/krona_cleanup'
include { KRONA_KTIMPORTTEXT } from '../../modules/nf-core/krona/ktimporttext/main'
include { KRONA_KTIMPORTTAXONOMY } from '../../modules/nf-core/krona/ktimporttaxonomy/main'
include { GUNZIP } from '../../modules/nf-core/gunzip/main'
workflow VISUALIZATION_KRONA {
take:
classifications
profiles
databases
main:
ch_krona_text = Channel.empty()
ch_krona_html = Channel.empty()
ch_versions = Channel.empty()
/*
Split profile results based on tool they come from
*/
ch_input_profiles = profiles
.branch {
centrifuge: it[0]['tool'] == 'centrifuge'
kraken2: it[0]['tool'] == 'kraken2'
unknown: true
}
ch_input_classifications = classifications
.branch {
kaiju: it[0]['tool'] == 'kaiju'
malt: it[0]['tool'] == 'malt'
unknown: true
}
/*
Convert Kraken2 formatted reports into Krona text files
*/
ch_kraken_reports = ch_input_profiles.kraken2
.mix( ch_input_profiles.centrifuge )
KRAKENTOOLS_KREPORT2KRONA ( ch_kraken_reports )
ch_krona_text = ch_krona_text.mix( KRAKENTOOLS_KREPORT2KRONA.out.txt )
ch_versions = ch_versions.mix( KRAKENTOOLS_KREPORT2KRONA.out.versions.first() )
/*
Combine Kaiju profiles with their databases
*/
ch_input_for_kaiju2krona = ch_input_classifications.kaiju
.map{ [it[0]['db_name'], it[0], it[1]] }
.combine( databases.map{ [it[0]['db_name'], it[1]] }, by: 0 )
.multiMap{
it ->
profiles: [it[1], it[2]]
db: it[3]
}
/*
Convert Kaiju formatted reports into Krona text files
*/
KAIJU_KAIJU2KRONA( ch_input_for_kaiju2krona.profiles, ch_input_for_kaiju2krona.db )
ch_krona_text = ch_krona_text.mix( KAIJU_KAIJU2KRONA.out.txt )
ch_versions = ch_versions.mix( KAIJU_KAIJU2KRONA.out.versions.first() )
/*
Remove taxonomy level annotations from the Krona text files
*/
KRONA_CLEANUP( ch_krona_text )
ch_cleaned_krona_text = KRONA_CLEANUP.out.txt
ch_versions = ch_versions.mix( KRONA_CLEANUP.out.versions.first() )
/*
Convert Krona text files into html Krona visualizations
*/
ch_krona_text_for_import = ch_cleaned_krona_text
.map{[[id: it[0]['db_name'], tool: it[0]['tool']], it[1]]}
.groupTuple()
KRONA_KTIMPORTTEXT( ch_krona_text_for_import )
ch_krona_html = ch_krona_html.mix( KRONA_KTIMPORTTEXT.out.html )
ch_versions = ch_versions.mix( KRONA_KTIMPORTTEXT.out.versions.first() )
/*
Convert MALT/MEGAN RMA2INFO files into html Krona visualisations
*/
if ( params.krona_taxonomy_directory ) {
MEGAN_RMA2INFO_KRONA ( ch_input_classifications.malt, false )
GUNZIP ( MEGAN_RMA2INFO_KRONA.out.txt )
ch_krona_taxonomy_for_input = GUNZIP.out.gunzip
.map{[[id: it[0]['db_name'], tool: it[0]['tool']], it[1]]}
.groupTuple()
KRONA_KTIMPORTTAXONOMY ( ch_krona_taxonomy_for_input, file(params.krona_taxonomy_directory, checkExists: true) )
ch_krona_html.mix( KRONA_KTIMPORTTAXONOMY.out.html )
ch_versions = ch_versions.mix( MEGAN_RMA2INFO_KRONA.out.versions.first() )
ch_versions = ch_versions.mix( KRONA_KTIMPORTTAXONOMY.out.versions.first() )
}
emit:
html = ch_krona_html
versions = ch_versions
}